AP‐2 is a recent significant addition to the list of transcription factors that have been demonstrated by targeted gene disruption to be essential for normal development. Two recent reports of AP‐2 null mutant mice(1,2) indicate that AP‐2 holds a key position in the network of genes and proteins controlling developmental pattern and morphogenesis, and that it is particularly important for development of the cranial region and for midline fusions.

Is it harder to acquire knowledge about things that really matter to us than it is to acquire knowledge about things we don't much care about? Jason Stanley 2005 argues that whether or not the relational predicate 'knows that' holds between an agent and a proposition can depend on the practical interests of the agent: the more it matters to a person whether p is the case, the more justification is required before she counts as knowing that p. The evidence (...) for Stanley's thesis includes a number of intuitive judgments about examples. In this paper we provide parallel examples for which Stanley's thesis requires unwelcome knowledge-attributions, and argue that this is possible because his thesis conflicts with familiar and plausible principles about knowledge. (shrink)

This chapter explores reasons to doubt the defensibility of the “weak theory of sustainability” that informs and justifies the use of cost-benefit analysis by environmental regulators. As the argument reveals, inasmuch as the weak theory equates what is sustainable with what sustains the satisfaction of human preferences, it has the surprising philosophical wherewithal to make climate-changing activities sustainable, at least in principle. This would be so if human ingenuity made possible the replacement of ecosystem services with technological alternatives. And it (...) would be particularly so if the aesthetic goods that derive from nature – goods which are resistant to quantification – are excluded from environmental cost-benefit analyses. But it is also true if those aesthetic goods are reduced to mere human preferences that can be measured through indirect market-based means, for aesthetic preferences are remarkably adaptive.Inasmuch as people can be expected to come to appreciate landscapes degraded by climate change, those who defend a weak theory of sustainability can expect that climate change will not long be at odds with what people find aesthetically pleasing. However, as the growing literature on “nature-deficit disorder” suggests, while aesthetic preferences may be elastic, aesthetic needs are not. As climate change progressively strips us of nature’s goods, we will lose the ability to meet crucial aesthetic needs. The irony is clear: As our aesthetic preferences bend towards the acceptance of ecological loss, we will predictably lose our preferences for meeting our own enduring aesthetic needs. We can thus expect climate change to cause us to prefer what we do not need and to need what we do not prefer. And this implies that climate change is the reductio ad absurdum of the weak theory of sustainability that dominates contemporary environmental regulation. (shrink)

Presents a plethora of approaches to developing human potential in areas not conventionally addressed. Organized in two parts, this international collection of essays provides viable educational alternatives to those currently holding sway in an era of high-stakes accountability.

In this brief, we argue that there is a diversity of ways in which humans (Homo sapiens) are ‘persons’ and there are no non-arbitrary conceptions of ‘personhood’ that can include all humans and exclude all nonhuman animals. To do so we describe and assess the four most prominent conceptions of ‘personhood’ that can be found in the rulings concerning Kiko and Tommy, with particular focus on the most recent decision, Nonhuman Rights Project, Inc v Lavery.

Santa Constanza est une des deux églises qui font partie de la première architecture chrétienne à Rome. Il ne reste aujourd'hui qu'un bâtiment circulaire de 29 m de diamètre. Il est probable que Santa Constanza fut à l'origine le mausolée impérial de la Via Nomentana à l'époque de l'empereur Julien. La mort de sa femme fut l'occasion de la construction de l'édifice. Nous possédons des preuves documentaires sur la sépulture de sa femme qui repose à côté de sa soeur. La (...) décoration de Santa Constanza semblait représenter et saluer l'ensemble des dieux, les païens et le chrétien. (shrink)

BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

Munich, Bayerische Staadtsbibliothek Ms. C.L.M. 4643 contains a curious commentary on Boethius's Arithmetica, which deals very fully with some passages in the work and totally neglects a great many others. The principal interest of the piece lies in the fact that the parts of the Arithmetica it selects for consideration are exactly those which were of special interest to twelfth- and early-thirteenth-century students, and in particular to the successors of Hugh of St. Victor who continued to draw on the Victorine (...) tradition. (shrink)

Machine generated contents note: -- Series Editors' PrefaceAcknowledgementsNotes on ContributorsHow Things Are Elsewhere; W. Schwarz Information Change and First-Order Dynamic Logic; B.Kooi Interpreting and Applying Proof Theories for Modal Logic; F.Poggiolesi & G.Restall The Logic(s) of Modal Knowledge; D.Cohnitz On Probabilistically Closed Languages; H.Leitgeb Dogmatism, Probability and Logical Uncertainty; B.Weatherson & D.Jehle Skepticism about Reasoning; S.Roush, K.Allen & I.HerbertLessons in Philosophy of Logic from Medieval Obligations; C.D.Novaes How to Rule Out Things with Words: Strong Paraconsistency and the Algebra of Exclusion; (...) F.Berto Lessons from the Logic of Demonstratives; G.RussellThe Multitude View on Logic; M.Eklund Index. (shrink)

Dr Gillian Craig (1) has argued that palliative medicine services have tended to adopt a policy of sedation without hydration, which under certain circumstances may be medically inappropriate, causative of death and distressing to family and friends. We welcome this opportunity to defend, with an important modification, the approach we proposed without substantive background argument in our original article (2). We maintain that slowing and eventual cessation of oral intake is a normal part of a natural dying process, that (...) artificial hydration and alimentation (AHA) are not justified unless thirst or hunger are present and cannot be relieved by other means, but food and fluids for (natural) oral consumption should never be 'withdrawn'. The intention of this practice is not to alter the timing of an inevitable death, and sedation is not used, as has been alleged, to mask the effects of dehydration or starvation. The artificial provision of hydration and alimentation is now widely accepted as medical treatment. We believe that arguments that it is not have led to confusion as to whether or not non-provision or withdrawal of AHA constitutes a cause of death in law. Arguments that it is such a cause appear to be tenuously based on an extraordinary/ordinary categorisation of treatments by Kelly (3) which has subsequently been interpreted as prescriptive in a way quite inconsistent with the Catholic moral theological tradition from which the distinction is derived. The focus of ethical discourse on decisions at the end of life should be shifted to an analysis of care, needs, proportionality of medical interventions, and processes of communication. (shrink)

I was quite excited when I first read Restall and Russell’s (2010) paper. For two reasons. First, because the paper provides rigorous formulations and formal proofs of implication barrier the- ses, namely “theses [which] deny that one can derive sentences of one type from sentences of another”. Second (and primarily), because the paper proves a general theorem, the Barrier Con- struction Theorem, which unifies implication barrier theses concerning four topics: generality, necessity, time, and normativity. After thinking about the paper, I (...) am satisfied with its treatment of the first three topics, namely generality, necessity, and time. But I am not satisfied with its treatment of normativity, so my comments are exclusively on that topic. (shrink)

Normativism is the view that logic provides rules for correct reasoning. Some influential critics of normativism, such as Gilbert Harman, claim that logical rules provide reasoners with bad or misleading standards. Others, such as Gillian Russell, claim that logic is a descriptive subject and thus cannot, given Hume’s law, provide rules for reasoning. We think these critics are mistaken. Our aim in this paper is to defend normativism by sketching an alternative way of thinking about the normative force of (...) logical rules. On our view, logical rules are best characterized, in a broadly Rossian manner, as intellectual prima facie duties; i.e., they provide standards for evaluating reasoning and reasoners that are universal and authoritative, but not absolute. This position accommodates the inherent normativity of logic, contra Russell, while circumventing the challenges to normativism raised by Harman. (shrink)

From Gillian Brock’s vigorous probing of my treatment of meeting needs in my book of that title I have learned a good deal; and from the article published in Dialogue, which concerns in particular the connection that I made between justice and needs, I have certainly learned how my arguments for that connection might have been expressed more cogently. Yet I think that the arguments I intended, and even the arguments I expressed, escape her criticisms. She quotes a number (...) of leading assertions drawn one by one from my text, but consolidates into one argument what are best regarded as three different, though connected, arguments, to the disadvantage of their respective strengths. She also disregards, to their disadvantage, the distinction between “respect for a person M’s position”—my phrasing, meaning M’s position under some assignment of benefits and burdens—and “respect for a person M”—a notion that does not come into the three arguments. (shrink)

From Gillian Brock's vigorous probing of my treatment of meeting needs in my book of that title I have learned a good deal; and from the article published in Dialogue, which concerns in particular the connection that I made between justice and needs, I have certainly learned how my arguments for that connection might have been expressed more cogently. Yet I think that the arguments I intended, and even the arguments I expressed, escape her criticisms. She quotes a number (...) of leading assertions drawn one by one from my text, but consolidates into one argument what are best regarded as three different, though connected, arguments, to the disadvantage of their respective strengths. She also disregards, to their disadvantage, the distinction between “respect for a person M's position”—my phrasing, meaning M's position under some assignment of benefits and burdens—and “respect for a person M”—a notion that does not come into the three arguments. (shrink)

In Mourning Becomes the Law, Gillian Rose takes us beyond the impasse of post-modernism or 'despairing rationalism withour reason'. Arguing that the post-modern search for a 'new ethics' and ironic philosophy are incoherent, she breathes new life into the debates concerning power and domination, transcendence and eternity. Mourning Becomes the Law is the philosophical counterpart to Gillian Rose's highly acclaimed memoir Love's Work. She extends similar clarity and insight to discussions of architecture, cinema, painting and poetry, through which (...) relations between the formation of the individual and the theory of justice are connected. At the heart of this reconnection lies a reflection on the significance of the Holocaust and Judaism. Mourning Becomes the Law reinvents the classical analogy of the soul, the city and the sacred. It returns philosophy, Nietzsche's 'bestowing virtue', to the pulse of our intellectual and political culture. (shrink)

This study described the relationships between academic class and student moral sensitivity and reasoning and between curriculum design components for ethics education and student moral sensitivity and reasoning. The data were collected from freshman (n = 506) and senior students (n = 440) in eight baccalaureate nursing programs in South Korea by survey; the survey consisted of the Korean Moral Sensitivity Questionnaire and the Korean Defining Issues Test. The results showed that moral sensitivity scores in patient-oriented care and conflict were (...) higher in senior students than in freshman students. Furthermore, more hours of ethics content were associated with higher principled thinking scores of senior students. Nursing education in South Korea may have an impact on developing student moral sensitivity. Planned ethics content in nursing curricula is necessary to improve moral sensitivity and moral reasoning of students. (shrink)

Our brains are us. But we are neither happy, fulfilled, nor all that we 'should' (or maybe could) be. We have everything previous generations could have dreamed of, but it seems it's never quite enough. What's going on? Has it anything to do with the way those brains have developed, by any chance? Gillian Bridge takes us on a journey through time, history and the mysterious labyrinth that is the brain, investigating strange happenings and unlikely people on the way. (...) The Significance Delusion is a challenging explanation of our species' peculiar vulnerability to disorders of both thinking and social cohesion. It is a power pack of research, ideas, facts and fascinating real life stories which explores our species' obsession with meaning and significance. What does it all mean for me? What do I mean to you? The Significance Delusion is humorous as well as deeply serious, and it is the must read compilation of lifestyle advice for tomorrow's well-adjusted people. It is a book about what it takes to thrive and survive as an individual human and as a society. From it you will learn the meaning of life, and your place in the world. For parents, educators, thinkers, psychologists, psychotherapists and policy makers. (shrink)

By executive order, the US adopted an immigration policy that looks remarkably similar to a Muslim ban, and threatened to deport long-settled residents, such as the so-called Dreamers. Our defunct refugee system has not dealt adequately with increased refugee flows, forcing desperate people to undertake increasingly risky measures in efforts to reach safe havens. Meanwhile increased migration flows over recent years appear to have contributed to a rise in right-wing populism, apparently driving phenomena such as Brexit and Trumpism. In this (...) original and insightful book Gillian Brock offers answers and tools that assist us in evaluating current migration policy and in helping to determine which policies may be permissible and which are normatively indefensible. She offers a comprehensive framework for responding to the many challenges which have recently emerged, and for delivering justice for people on the move along with those affected by migration. (shrink)

As global business operations expand, managers need more knowledge of foreign cultures, in particular, information on the ethics of doing business across borders. The purpose of this paper is twofold: to share the Islamic perspective on business ethics, little known in the west, which may stimulate further thinking and debate on the relationships between ethics and business, and to provide some knowledge of Islamic philosophy in order to help managers do business in Muslim cultures. The case of Egypt illustrates some (...) divergence between Islamic philosophy and practice in economic life. The paper concludes with managerial implications and suggestions for further research. (shrink)

Nancy Cartwright's 1983 book How the Laws of Physics Lie argued that theories of physics often make use of idealisations, and that as a result many of these theories were not true. The present paper looks at idealisation in logic and argues that, at least sometimes, the laws of logic fail to be true. That might be taken as a kind of skepticism, but I argue rather that idealisation is a legitimate tool in logic, just as in physics, and recognising (...) this frees logicians up to use false laws where these are helpful. (shrink)

Socioeconomic differences in behaviour are pervasive and well documented, but their causes are not yet well understood. Here, we make the case that a cluster of behaviours is associated with lower socioeconomic status, which we call “the behavioural constellation of deprivation.” We propose that the relatively limited control associated with lower SES curtails the extent to which people can expect to realise deferred rewards, leading to more present-oriented behaviour in a range of domains. We illustrate this idea using the specific (...) factor of extrinsic mortality risk, an important factor in evolutionary theoretical models. We emphasise the idea that the present-oriented behaviours of the constellation are a contextually appropriate response to structural and ecological factors rather than a pathology or a failure of willpower. We highlight some principles from evolutionary theoretical models that can deepen our understanding of how socioeconomic inequalities can become amplified and embedded. These principles are that small initial disparities can lead to larger eventual inequalities, feedback loops can embed early-life circumstances, constraints can breed further constraints, and feedback loops can operate over generations. We discuss some of the mechanisms by which SES may influence behaviour. We then review how the contextually appropriate response perspective that we have outlined fits with other findings about control and temporal discounting. Finally, we discuss the implications of this interpretation for research and policy. (shrink)

Between Feminism and Materialism is a bold attempt to make sense of the relationship between feminist theory and capitalism. Addressing a number of philosophical problems that have engaged feminists over the last few decades - universals and reason, nature and essentialism, identity and non-identity, sex and gender, power and patriarchy, local and global - this innovative book breaks through feminist waves and explains the paradoxes of feminist theory by demonstrating the on-going relevance of dialectics and the concepts of exploitation, ideology, (...) and reification. Drawing on first, second and third 'waves' of feminist theory, this exciting combination of existentialism, phenomenology and critical theory delivers a problem-based, micro-political and coalitional feminism ready to respond to the challenges presented by our thoroughly modern times. (shrink)

This paper examines beliefs about four aspects of ethical leadership – Character/Integrity, Altruism, Collective Motivation and Encouragement – in Germany and the United States using data from Project GLOBE (Global Leadership and Organizational Behavior Effectiveness) and a supplemental analysis. Within the context of a push toward convergence driven by the demands of globalization and the pull toward divergence underpinned by different cultural values and philosophies in the two countries, we focus on two questions: Do middle managers from the United States (...) and Germany differ in their beliefs about ethical leadership? And, do individuals from these two countries attribute different characteristics to ethical leaders? Results provide evidence that while German and US middle managers, on average, differed in the degree of endorsement for each aspect, they each endorsed Character/Integrity, Collective Motivation and Encouragement as important for effective leadership and had a more neutral view of the importance of Altruism . The findings are reviewed within the social-cultural context of each country. (shrink)

This paper examines beliefs about four aspects of ethical leadership –Character/Integrity, Altruism, Collective Motivation and Encouragement– in Germany and the United States using data from Project GLOBE (Global Leadership and Organizational Behavior Effectiveness) and a supplemental analysis. Within the context of a push toward convergence driven by the demands of globalization and the pull toward divergence underpinned by different cultural values and philosophies in the two countries, we focus on two questions: Do middle managers from the United States and Germany (...) differ in their beliefs about ethical leadership? And, do individuals from these two countries attribute different characteristics to ethical leaders? Results provide evidence that while German and US middle managers, on average, differed in the degree of endorsement for each aspect, they each endorsed Character/Integrity, Collective Motivation and Encouragement as important for effective leadership and had a more neutral view of the importance of Altruism. The findings are reviewed within the social-cultural context of each country. (shrink)

Gillian Brock develops a model of global justice that takes seriously the moral equality of all human beings notwithstanding their legitimate diverse identifications and affiliations. She addresses concerns about implementing global justice, showing how we can move from theory to feasible public policy that makes progress toward global justice.